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746534 : Laboratoire de Physiologie et Génomique des Poissons (LPGP) - Cote = 2012


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Ouvrage The operon model and its impact on modern biology : Special issue
2011 . Elsevier , San Diego , 87 p.


MAMMIFERE ; VERTEBRE ; SOURIS ; OPERON ; EPIGENETIQUE ; GENE ; REGULATION GENIQUE ; EXPRESSION DES GENES ; PROTEINE ; TRANSCRIPTION ; TRANSMISSION ; INFORMATION ; COMPLEXITE ; CYCLE CELLULAIRE ; DIVISION CELLULAIRE ; HISTONE ; RNA ; ADN ; METHYLATION DE L'ADN ; CHROMATINE ; CHROMOSOME ; INHERITANCE
746375 : Laboratoire de Physiologie et Génomique des Poissons (LPGP) Cote - Tapas


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Ouvrage RNAI & miRNA Europe qPCR Europe. Epigenetics Europe - Genomics automation Europe, 14-15 september 2010, Dublin (Ireland) : Proceedings
2010 . , n.p.


CONGRES ; DUBLIN ; IRLANDE ; RNA
EUROPE
746201 : Laboratoire de Physiologie et Génomique des Poissons (LPGP) - Cote = C2010/2


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Article Genetic linkage and expression analysis of SREBP and lipogenic genes in fat and lean chicken   Assaf, Sirine ; Lagarrigue, Sandrine ; Daval, Stéphanie ; Sansom, Manuella ; Leclercq, Bernard ; Michel, Joël ; Pitel, Frédérique ; Alizadeh, Mehdi ; Vignal, Alain ; Douaire, Madeleine
Comparative Biochemistry and Physiology B Biochemistry and Molecular Biology, 2004 , Volume 4 , n° 137 , 433-441 p.   [ ISSN : 0305-0491 ]
Résumé :
To identify the genes directly responsible, through DNA polymorphism, for the difference in fatness observed between a lean and a fat chicken line, we studied five genes (ACL, ACC, FAS, ME, SCD1) encoding key enzymes involved in liver fatty acid synthesis and secretion. Genetic linkage was tested...

Adipose Tissue ; Alleles ; ANALYSIS ; Animals ; Base Sequence ; Biosynthesis ; CCAAT-Enhancer-Binding Proteins ; Chickens ; DNA ; DNA-Binding Proteins ; ENZYME ; ENZYMES ; Enzymology ; Fatty Acids ; Gene Expression Regulation ; GENES ; GENETIQUE ; Growth & dévelopment ; Linkage (Genetics) ; Liver ; Metaboslim ; Molecular Sequence Data ; Obesity ; RECHERCHE ; Research Support,Non-U.S.Gov't ; RNA ; RNA Processing,Post-Transcriptional ; RNA,Messenger ; SECRETION ; Secrétion ; Thinness ; TRANSCRIPTION ; Transcription Factors
401107 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article A functional approach to fattening in chickens   Bourneuf, Emmanuelle ; Herault, Frédéric ; Retout, Elodie ; Lagarrigue, Sandrine ; Douaire, Madeleine ; Diot, Christian
British Poultry Science, 2003 , Volume 44 , n° 44 , 793-794 p.   [ ISSN : 0007-1668 ]


Animals ; Chickens ; Comparative Study ; Gene Library ; GENETIQUE ; Growth & dévelopment ; Isolation & purification ; Liver ; Nucleic Acid Hybridization ; PHYSIOLOGY ; Polymerase Chain Reaction ; RNA ; Weight Gain
401096 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Cloning of cDNA encoding the nuclear form of chicken sterol response element binding protein-2 (SREBP-2), chromosomal localization, and tissue expression of chicken SREBP-1 and -2 genes   Assaf, Sirine ; Hazard, Dominique ; Pitel, Frédérique ; Morisson, Mireille ; Alizadeh, Mehdi ; Gondret, Florence ; Diot, Christian ; Vignal, Alain ; Douaire, Madeleine ; Lagarrigue, Sandrine
Poult Sci, 2003 , Volume 1 , n° 82 , 54-61 p.   [ ISSN : 0032-5791 ]
Résumé :
Sterol regulatory element binding protein-1 and -2 (SREBP-1 and -2) are key transcription factors involved in the biosynthesis of cholesterol and fatty adds. The SREBP have mainly been studied in rodents in which lipogenesis is regulated in both liver and adipose tissue. There is, however, a...

Adipose Tissue ; Amino Acid Sequence ; ANALYSIS ; Animals ; Biosynthesis ; Blotting,Northern ; CCAAT-Enhancer-Binding Proteins ; cDNA ; CHEMISTRY ; Chickens ; CHROMOSOME ; Chromosome Mapping ; Chromosomes ; Cloning,Molecular ; Comparative Study ; CONSERVATION ; DNA ; DNA,Complementary ; DNA-Binding Proteins ; Gene Expression ; GENES ; GENETIQUE ; Hamsters ; Humans ; Liver ; METABOLISM ; Metaboslim ; Mice ; Molecular Sequence Data ; Organ Specificity ; Polymorphism,Genetic ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; RNA,Messenger ; Sequence Homology ; TRANSCRIPTION ; Transcription Factors
401159 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Comparative effect of fenofibrate on hepatic desaturases in wild-type and peroxisome proliferator-activated receptor alpha-deficient mice   Guillou, Hervé ; Martin, Pascal ; Jan, Sophie ; D'Andrea, Sabine ; Roulet, Alain ; Catheline, Daniel ; Rioux, Vincent ; Pineau, Thierry ; Legrand, Philippe
Lipids, 2002 , Volume 37 , n° 37 , 981-989 p.   [ ISSN : 0024-4201 ]
Résumé :
In this study is presented the effect of fenofibrate, a prototypical peroxisome proliferator of the fibrate class, on wild-type and peroxisome proliferator-activated receptor alpha (PPARalpha)-/- mouse liver FA profile, desaturase mRNA levels, and activities. We established that, following...

ANALYSIS ; Animals ; BIOCHIMIE ; Body Weight ; deficiency ; DESATURASE ; Drug effects ; Enzymology ; Fatty Acid Desaturases ; Fatty Acids ; FRANCE ; GENETIQUE ; Liver ; MALE ; METABOLISM ; Mice ; Mice,Knockout ; Organ Size ; pharmacology ; Procetofen ; Receptors,Cytoplasmic and Nuclear ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Time Factors ; TRANSCRIPTION ; Transcription Factors
401147 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Differential expression and genetic variation of hepatic messenger RNAs from genetically lean and fat chickens   Carre W ; Bourneuf, Emmanuelle ; Douaire, Madeleine ; Diot, Christian
Gene, 2002 , n° 299 , 235-243 p.   [ ISSN : 0378-1119 ]
Résumé :
Although excessive adiposity has become a major drawback in meat type chicken production, few of the genes involved in this process have been characterized so far. In order to identify putative genes involved in adiposity, we performed differential display analysis of RNAs extracted from the...

Adipose Tissue ; ANALYSE ; ANALYSIS ; Animals ; Base Sequence ; Blotting,Northern ; Body Weight ; CHEMISTRY ; Chickens ; Cytochrome P-450 Enzyme System ; DNA ; DNA,Complementary ; ENZYME ; FRANCE ; Gene Expression Profiling ; GENES ; GENETIQUE ; Humans ; Liver ; METABOLISM ; Metaboslim ; Molecular Sequence Data ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; RNA,Messenger ; Sequence Alignment ; Sequence Analysis,DNA ; Sequence Homology,Nucleic Acid ; Tumor Cells,Cultured ; VARIATION ; Variation (Genetics)
401119 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Characterization of syndecan-4 expression in 3T3-F442A mouse adipocytes: link between syndecan-4 induction and cell proliferation   Landry, Reiko Y. ; Rioux, Vincent ; Bensadoun, André
Cell Growth Differ, 2001 , Volume 12 , n° 12 , 497-504 p.   [ ISSN : 1044-9523 ]
Résumé :
Heparan sulfate proteoglycans are found on the surface of most cells. Syndecan-4 is a widely expressed transmembrane heparan sulfate proteoglycan. Using quantitative RNase protection assays and immunoblotting, syndecan-4 expression was characterized in 3T3-F442A mouse adipoblasts. These cells...

3T3 Cells ; ADIPOCYTES ; Animals ; Biosynthesis ; Cell Division ; Cell Line ; DNA ; DNA,Complementary ; Dose-Response Relationship,Drug ; Immunoblotting ; Membrane Glycoproteins ; METABOLISM ; Mice ; Oligonucleotides,Antisense ; pharmacology ; Proteoglycans ; Research Support,U.S.Gov't,P.H.S. ; RIBONUCLEASES ; RNA ; RNA,Messenger ; Time Factors
401098 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Development of 112 unique expressed sequence tags from chicken liver using an arbitrarily primed reverse transcriptase-polymerase chain reaction and single strand conformation gel purification method   Carre W ; Diot, Christian ; Fillon, Valérie ; Crooijmans, Richard P.M.A. ; Lagarrigue, Sandrine ; Morisson, Mireille ; Vignal, Alain ; Groenen, Martien A. ; Douaire, Madeleine
Anim Genet, 2001 , Volume 5 , n° 32 , 289-297 p.   [ ISSN : 0268-9146 ]
Résumé :
In order to provide information on chicken genome expression, expressed sequence tags (ESTs) were developed from chicken liver RNAs using a method based on arbitrarily primed reverse transcription-polymerase chain reaction (RT-PCR) of total RNAs. The method is similar to differential display,...

ANALYSIS ; Animals ; Chickens ; Expressed Sequence Tags ; FRANCE ; GENES ; GENETIQUE ; Humans ; In Situ Hybridization,Fluorescence ; Liver ; Metaboslim ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; Sequence Alignment ; Synteny
401076 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Stearoyl coenzyme A desaturase 1 expression and activity are increased in the liver during iron overload   Pigeon, Christelle ; Legrand, Philippe ; Leroyer, Patricia ; Bouriel, Monique ; Turlin, Bruno ; Brissot, Pierre ; Loreal, Olivier
Biochimica et Biophysica Acta, 2001 , Volume 3 , n° 1535 , 275-284 p.   [ ISSN : 0006-3002 ]
Résumé :
In humans, hepatic iron overload can lead to hepatocellular carcinoma development. Iron related dysregulation of hepatic genes could play a role in this phenomenon. We previously found that the carbonyl-iron overloaded mouse was a useful model to study the mechanisms involved in the development...

ANALYSIS ; Animals ; Biosynthesis ; DESATURASE ; Disease Models,Animal ; Drug effects ; ENZYME ; Enzyme Activation ; Enzymology ; Fatty Acids ; FOIE ; FRANCE ; Gene Expression Regulation ; GENES ; GENETIQUE ; Humans ; Iron Overload ; Iron-Dextran Complex ; Liver ; MALE ; METABOLISM ; Mice ; Mice,Inbred BALB C ; Organometallic Compounds ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Stearoyl-CoA Desaturase ; Up-Regulation
401093 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Messenger RNA levels and transcription rates of hepatic lipogenesis genes in genetically lean and fat chickens   Daval, Stéphanie ; Lagarrigue, Sandrine ; Douaire, Madeleine
Genet Sel Evol, 2000 , Volume 5 , n° 32 , 521-531 p.   [ ISSN : 0999-193X ]
Résumé :
Levels of body fat content in commercial meat chickens have prompted research in order to control the development of this trait. Based on experimentally selected divergent lean and fat lines, many studies have shown that liver metabolism has a major role in the fatness variability. In order to...

Acetyl-CoA Carboxylase ; Chickens ; ENZYME ; ENZYMES ; GENES ; Liver ; METABOLISM ; Metaboslim ; RECHERCHE ; RNA ; Stearoyl-CoA Desaturase ; TRANSCRIPTION
401120 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Stearoyl-CoA desaturase 1 coding sequences and antisense RNA affect lipid secretion in transfected chicken LMH hepatoma cells   Diot, Christian ; Lefèvre, Pascal ; Hervé, Christophe ; Belloir, Bénédicte ; Narce, Michel ; Damon, Marie ; Poisson, Jean-Pierre ; Mallard, Jacques ; Douaire, Madeleine
Arch Biochem Biophys, 2000 , Volume 2 , n° 380 , 243-250 p.   [ ISSN : 0003-9861 ]
Résumé :
Hepatic stearoyl CoA desaturase (SCD) activity in chickens from a fat line is higher than that of chickens from a lean line and correlates with plasma triacylglycerol concentrations. Furthermore, in these lines, the hepatic SCD1 mRNA level is positively correlated with the adipose tissue weight....

Adipose Tissue ; Animals ; Base Sequence ; Chickens ; DNA ; DNA Primers ; Drug effects ; Enzymology ; Gene Expression ; GENETIQUE ; ISOENZYMES ; Lipids ; Liver ; Liver Neoplasms,Experimental ; LMH ; Metaboslim ; pharmacology ; PLASMA ; Recombinant Proteins ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Antisense ; RNA,Messenger ; RNA,Neoplasm ; SECRETION ; Secrétion ; Stearoyl-CoA Desaturase ; TRANSFECTION ; Tumor Cells,Cultured
401083 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Hormonal regulation of stearoyl coenzyme-A desaturase 1 activity and gene expression in primary cultures of chicken hepatocytes   Lefèvre, Pascal ; Diot, Christian ; Legrand, Philippe ; Douaire, Madeleine
Arch Biochem Biophys, 1999 , Volume 2 , n° 368 , 329-337 p.   [ ISSN : 0003-9861 ]
Résumé :
Previous studies have provided evidence for the important role of liver stearoyl-CoA desaturase (SCD) in excessive adiposity in the chicken and suggest that the difference in SCD activity between fat and lean chickens could be explained by a difference in SCD1 gene expression. In the present...

ANALYSIS ; Animals ; BIOCHIMIE ; Cells,Cultured ; Chickens ; DESATURASE ; Drug effects ; ENZYME ; Enzymology ; FRANCE ; Gene Expression ; Gene Expression Regulation,Enzymologic ; GENES ; GENETIQUE ; GLUCAGON ; HEPATOCYTE ; Hypoglycemic Agents ; Insulin ; Liver ; METABOLISM ; pharmacology ; Protein Synthesis Inhibitors ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Stearoyl-CoA Desaturase ; TRANSCRIPTION
401084 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Characterization of the chicken fatty acid synthase gene 5' part and promoter region   Le Fur, Nathalie ; El Khadir-Mounier, Catherine ; Powell, Rohan S. ; Diot, Christian ; Mallard, Jacques ; Douaire, Madeleine
Eur J Biochem, 1996 , Volume 2 , n° 240 , 323-330 p.   [ ISSN : 0014-2956 ]
Résumé :
Fatty acid synthase activity has been shown to be regulated mainly at the transcriptional level under both dietary and hormonal influences. As a first step towards elucidating the factors involved, we isolated and characterized chicken genomic clones encompassing the 5' part of the chicken fatty...

Animals ; Base Sequence ; cDNA ; Chickens ; Chloramphenicol O-Acetyltransferase ; Cloning,Molecular ; Codon,Initiator ; Conserved Sequence ; DNA ; DNA,Complementary ; EXONS ; Fatty Acid Synthetase Complex ; Genes,Reporter ; GENETIQUE ; Liver ; METABOLISM ; Molecular Sequence Data ; Promoter Regions (Genetics) ; Research Support,Non-U.S.Gov't ; Restriction Mapping ; RIBONUCLEASES ; RNA ; RNA,Messenger ; Sequence Analysis,DNA ; TRANSCRIPTION ; Transcription Factors ; Transcription,Genetic ; TRANSFECTION
401113 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Cloning and characterization of the 5' end and promoter region of the chicken acetyl-CoA carboxylase gene   El Khadir-Mounier, Catherine ; Le Fur, Nathalie ; Powell, Rohan S. ; Diot, Christian ; Langlois P ; Mallard, Jacques ; Douaire, Madeleine
Biochem J, 1996 , n° 314 ( Pt 2) , 613-619 p.   [ ISSN : 0264-6021 ]
Résumé :
Acetyl-CoA carboxylase is a rate-limiting enzyme in the biogenesis of long-chain fatty acids. In the present study, the 5' end and flanking region of the acetyl-CoA carboxylase (ACC) gene was analysed in the chicken. A genomic clone was isolated containing the first three exons, the third one...

Acetyl-CoA Carboxylase ; ANALYSE ; ANALYSIS ; Animals ; Base Sequence ; Cell Line ; Chickens ; Cloning,Molecular ; DNA ; DNA,Complementary ; ENZYME ; EXONS ; Fatty Acids ; Gene Expression ; GENETIQUE ; Humans ; Liver ; Molecular Sequence Data ; PCR ; Polymerase Chain Reaction ; Promoter Regions (Genetics) ; RAT ; Research Support,Non-U.S.Gov't ; Restriction Mapping ; RNA ; RNA Splicing ; RNA,Messenger ; TRANSCRIPTION ; Transcription,Genetic ; TRANSFECTION
401088 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Colloque Inhibition of lipid secretion in transfected chicken LMH cells expressing stearoyl-CoA desaturase 1 anti-sens RNA ( 1996 ) Diot, Christian ; You V ; Hervé, Christophe ; Douaire, Madeleine  
401213 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
ANIMAL ; Antisens ; CONGRES ; GENETIQUE ; GENETIQUE ; GENETIQUE ANIMALE ; LMH ; RNA ; SECRETION ; Stearoyl-CoA Desaturase

Article Stearoyl-CoA desaturase activity in primary culture of chicken hepatocytes. Influence of insulin, glucocorticoid, fatty acids and cordycepin   Legrand, Philippe ; Catheline, Daniel ; Hannetel, Jean-Michel ; Lemarchal, Philippe
Int J Biochem, 1994 , Volume 6 , n° 26 , 777-785 p.   [ ISSN : 0020-711X ]
Résumé :
1. Stearoyl-CoA desaturase (delta 9-desaturase) activity was measured in chicken primary hepatocytes, as a function of time in culture. 2. When using fasted donor animals, the desaturase activity was low at the beginning of culture and then increased steadily to a maximum value between 30 and 70...

ANIMAL ; Animals ; BIOCHIMIE ; Cells,Cultured ; Chickens ; Culture Media ; cytology ; Deoxyadenosines ; DESATURASE ; Dexamethasone ; Drug effects ; ENZYME ; Enzymology ; Fasting ; Fatty Acids ; FRANCE ; GENETIQUE ; HEPATOCYTE ; Insulin ; Linoleic Acid ; Linoleic Acids ; Liver ; MALE ; METABOLISM ; pharmacology ; Protein Biosynthesis ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Stearoyl-CoA Desaturase
401133 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Lipogenic enzyme and apoprotein messenger RNAs in long-term primary culture of chicken hepatocytes   Douaire, Madeleine ; Belloir, Bénédicte ; Guillemot JC ; Fraslin, Jean-Marc ; Langlois P ; Mallard, Jacques
J Cell Sci, 1993 , n° 104 ( Pt 3) , 713-718 p.   [ ISSN : 0021-9533 ]
Résumé :
Hepatocytes isolated from 9-week-old chickens were cultured in a serum-free, hormonally defined medium. Relative amounts of mRNAs coding for lipogenic enzymes (acetyl-CoA carboxylase, fatty acid synthase, delta 9 desaturase, malic enzyme) and apoproteins (apoprotein A1 and apoprotein B) were...

Acetyl-CoA Carboxylase ; Animals ; Apoproteins ; Biosynthesis ; Cells,Cultured ; Chickens ; cytology ; DESATURASE ; ENZYME ; ENZYMES ; Fatty Acid Desaturases ; Fatty Acid Synthetase Complex ; FRANCE ; GENETIQUE ; HEPATOCYTE ; Lipids ; Liver ; Malate Dehydrogenase ; MALE ; METABOLISM ; RECHERCHE ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; SECRETION ; Time Factors
401136 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Identifying genes involved in the variability of genetic fatness in the growing chicken   Douaire, Madeleine ; Le Fur, Nathalie ; El Khadir-Mounier, Catherine ; Langlois P ; Flamant F ; Mallard, Jacques
Poult Sci, 1992 , Volume 11 , n° 71 , 1911-1920 p.   [ ISSN : 0032-5791 ]
Résumé :
A precise knowledge of the genome involved in the expression of a quantitative trait could provide a useful tool in breeding programs molecular genetic methods are capable of yielding this kind of information. An experimental procedure is presented here for identifying genes whose expression is...

Adipose Tissue ; ANALYSIS ; Animals ; Apoproteins ; Biosynthesis ; Breeding ; Chickens ; ENZYME ; ENZYMES ; Fatty Acids ; Gene Expression Regulation ; GENES ; GENETIQUE ; growth & development ; Lipids ; Liver ; MALE ; METABOLISM ; METHODS ; PHYSIOLOGY ; PLASMA ; RECHERCHE ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; SECRETION ; Variation (Genetics) ; VLDL
401161 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
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