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Article The surprising diversity of Delta6-desaturase substrates   Guillou, Hervé ; D'Andrea, Sabine ; Rioux, Vincent ; Jan, Sophie ; Legrand, Philippe
Biochemical Society Transactions, 2004 , Volume Pt 1 , n° 32 , 86-87 p.   [ ISSN : 0300-5127 ]
Résumé :
A single gene encoding a Delta6-desaturase (FADS2) has been isolated and characterized in mammalian species. This Delta6-desaturase plays a major role in the biosynthesis of PUFAs (polyunsaturated fatty acids). It catalyses the rate-limiting desaturation of linoleic acid (C(18:2) n-6) and...

Animals ; BIOCHIMIE ; Biosynthesis ; Catalysis ; DESATURASE ; Fatty Acid Desaturases ; Fatty Acids ; Fatty Acids,Unsaturated ; FRANCE ; Humans ; METABOLISM ; Palmitic Acid ; Substrate Specificity
401089 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Cloning of cDNA encoding the nuclear form of chicken sterol response element binding protein-2 (SREBP-2), chromosomal localization, and tissue expression of chicken SREBP-1 and -2 genes   Assaf, Sirine ; Hazard, Dominique ; Pitel, Frédérique ; Morisson, Mireille ; Alizadeh, Mehdi ; Gondret, Florence ; Diot, Christian ; Vignal, Alain ; Douaire, Madeleine ; Lagarrigue, Sandrine
Poult Sci, 2003 , Volume 1 , n° 82 , 54-61 p.   [ ISSN : 0032-5791 ]
Résumé :
Sterol regulatory element binding protein-1 and -2 (SREBP-1 and -2) are key transcription factors involved in the biosynthesis of cholesterol and fatty adds. The SREBP have mainly been studied in rodents in which lipogenesis is regulated in both liver and adipose tissue. There is, however, a...

Adipose Tissue ; Amino Acid Sequence ; ANALYSIS ; Animals ; Biosynthesis ; Blotting,Northern ; CCAAT-Enhancer-Binding Proteins ; cDNA ; CHEMISTRY ; Chickens ; CHROMOSOME ; Chromosome Mapping ; Chromosomes ; Cloning,Molecular ; Comparative Study ; CONSERVATION ; DNA ; DNA,Complementary ; DNA-Binding Proteins ; Gene Expression ; GENES ; GENETIQUE ; Hamsters ; Humans ; Liver ; METABOLISM ; Metaboslim ; Mice ; Molecular Sequence Data ; Organ Specificity ; Polymorphism,Genetic ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; RNA,Messenger ; Sequence Homology ; TRANSCRIPTION ; Transcription Factors
401159 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Differential expression and genetic variation of hepatic messenger RNAs from genetically lean and fat chickens   Carre W ; Bourneuf, Emmanuelle ; Douaire, Madeleine ; Diot, Christian
Gene, 2002 , n° 299 , 235-243 p.   [ ISSN : 0378-1119 ]
Résumé :
Although excessive adiposity has become a major drawback in meat type chicken production, few of the genes involved in this process have been characterized so far. In order to identify putative genes involved in adiposity, we performed differential display analysis of RNAs extracted from the...

Adipose Tissue ; ANALYSE ; ANALYSIS ; Animals ; Base Sequence ; Blotting,Northern ; Body Weight ; CHEMISTRY ; Chickens ; Cytochrome P-450 Enzyme System ; DNA ; DNA,Complementary ; ENZYME ; FRANCE ; Gene Expression Profiling ; GENES ; GENETIQUE ; Humans ; Liver ; METABOLISM ; Metaboslim ; Molecular Sequence Data ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; RNA,Messenger ; Sequence Alignment ; Sequence Analysis,DNA ; Sequence Homology,Nucleic Acid ; Tumor Cells,Cultured ; VARIATION ; Variation (Genetics)
401119 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Effects of introducing linseed in livestock diet on blood fatty acid composition of consumers of animal products   Weill, Pierre ; Schmitt, Bernard ; Chesneau, Guillaume ; Daniel, Norohanta ; Safraou, Faouzi ; Legrand, Philippe
Ann Nutr Metab, 2002 , Volume 5 , n° 46 , 182-191 p.   [ ISSN : 0250-6807 ]
Résumé :
Reducing the ratio between essential fatty acids: C18:2 n-6/C18:3 n-3 down to 5 is recommended by Nutritional Guidelines. We studied the fatty acid (FA) changes in consumers' plasma following changes in livestock diet. First, a zootechnical study introduced 5% of extruded linseed into the diet of...

Adult ; ANIMAL ; Animal Feed ; Animals ; Animals,Domestic ; Blood ; Cardiovascular Diseases ; Cross-Over Studies ; Double-Blind Method ; Erythrocytes ; Fatty Acids ; Female ; Flax ; FRANCE ; Humans ; Linoleic Acid ; Linoleic Acids ; MALE ; Middle Aged ; PLASMA ; prevention & control
401081 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Development of 112 unique expressed sequence tags from chicken liver using an arbitrarily primed reverse transcriptase-polymerase chain reaction and single strand conformation gel purification method   Carre W ; Diot, Christian ; Fillon, Valérie ; Crooijmans, Richard P.M.A. ; Lagarrigue, Sandrine ; Morisson, Mireille ; Vignal, Alain ; Groenen, Martien A. ; Douaire, Madeleine
Anim Genet, 2001 , Volume 5 , n° 32 , 289-297 p.   [ ISSN : 0268-9146 ]
Résumé :
In order to provide information on chicken genome expression, expressed sequence tags (ESTs) were developed from chicken liver RNAs using a method based on arbitrarily primed reverse transcription-polymerase chain reaction (RT-PCR) of total RNAs. The method is similar to differential display,...

ANALYSIS ; Animals ; Chickens ; Expressed Sequence Tags ; FRANCE ; GENES ; GENETIQUE ; Humans ; In Situ Hybridization,Fluorescence ; Liver ; Metaboslim ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; Sequence Alignment ; Synteny
401076 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Probing the differences between rat liver outer mitochondrial membrane cytochrome b5 and microsomal cytochromes b5   Altuve, Adriana ; Silchenko, Svetlana ; Lee, Kyung-Hoon ; Kuczera, Krzysztof ; Terzyan, Simon ; Zhang, Xuejun ; Benson, David R. ; Rivera, Mario
Biochemistry, 2001 , Volume 40 , n° 40 , 9469-9483 p.   [ ISSN : 0006-2960 ]
Résumé :
Two distinct forms of cytochrome b5 exist in the rat hepatocyte. One is associated with the membrane of the endoplasmic reticulum (microsomal, or Mc, cyt b5) while the other is associated with the outer membrane of liver mitochondria (OM cyt b5). Rat OM cyt b5, the only OM cyt b5 identified so...

Amino Acid Sequence ; ANALYSIS ; Animals ; Binding Sites ; CATTLE ; CHEMISTRY ; COMPUTER SIMULATION ; Cytochromes b5 ; Endoplasmic Reticulum ; Hemin ; Humans ; Liver ; Magnetic Resonance Spectroscopy ; METABOLISM ; Microsomes ; Mitochondria,Liver ; Models,Molecular ; Molecular Sequence Data ; Molecular Structure ; Mutagenesis,Site-Directed ; Protein Denaturation ; Protein Isoforms ; Protein Structure,Tertiary ; Proteins ; RAT ; RATS ; Research Support,Non-U.S.Gov't ; Research Support,U.S.Gov't,Non-P.H.S. ; Research Support,U.S.Gov't,P.H.S. ; Sequence Alignment ; TEMPERATURE ; WATER
401090 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Stearoyl coenzyme A desaturase 1 expression and activity are increased in the liver during iron overload   Pigeon, Christelle ; Legrand, Philippe ; Leroyer, Patricia ; Bouriel, Monique ; Turlin, Bruno ; Brissot, Pierre ; Loreal, Olivier
Biochimica et Biophysica Acta, 2001 , Volume 3 , n° 1535 , 275-284 p.   [ ISSN : 0006-3002 ]
Résumé :
In humans, hepatic iron overload can lead to hepatocellular carcinoma development. Iron related dysregulation of hepatic genes could play a role in this phenomenon. We previously found that the carbonyl-iron overloaded mouse was a useful model to study the mechanisms involved in the development...

ANALYSIS ; Animals ; Biosynthesis ; DESATURASE ; Disease Models,Animal ; Drug effects ; ENZYME ; Enzyme Activation ; Enzymology ; Fatty Acids ; FOIE ; FRANCE ; Gene Expression Regulation ; GENES ; GENETIQUE ; Humans ; Iron Overload ; Iron-Dextran Complex ; Liver ; MALE ; METABOLISM ; Mice ; Mice,Inbred BALB C ; Organometallic Compounds ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Stearoyl-CoA Desaturase ; Up-Regulation
401093 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Characterization of a cDNA sequence encoding the peroxisome proliferator activated receptor alpha in the chicken   Diot, Christian ; Douaire, Madeleine
Poult Sci, 1999 , Volume 8 , n° 78 , 1198-1202 p.   [ ISSN : 0032-5791 ]
Résumé :
Peroxisome proliferator-activated receptors (PPAR) belong to the superfamily of the nuclear hormone receptors that play an important role in lipid homeostasis. A partial complementary deoxyribonucleic acid clone encoding a PPAR alpha from chicken liver was isolated and sequenced. Comparison with...

Amino Acid Sequence ; ANIMAL ; Animals ; Base Sequence ; cDNA ; Chickens ; DNA ; DNA,Complementary ; Gene Expression Regulation ; GENETIQUE ; Homeostasis ; Humans ; Lipids ; Liver ; METABOLISM ; Mice ; Molecular Sequence Data ; Peroxisome Proliferators ; RAT ; RATS ; Receptors,Cytoplasmic and Nuclear ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Analysis,DNA ; Sequence Homology ; Xenopus
401160 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Mapping of FASN and ACACA on two chicken microchromosomes disrupts the human 17q syntenic group well conserved in mammals   Pitel, Frédérique ; Fillon, Valérie ; Heimel C ; Le Fur, Nathalie ; Khadir-Mounier C ; Douaire, Madeleine ; Gellin, Joël ; Vignal, Alain
Mamm Genome, 1998 , Volume 4 , n° 9 , 297-300 p.   [ ISSN : 0938-8990 ]
Résumé :
Fatty acid synthase and Acetyl-CoA carboxylase are both key enzymes of lipogenesis and may play a crucial role in the weight variability of abdominal adipose tissue in the growing chicken. They are encoded by the FASN and ACACA genes, located on human Chromosome (Chr) 17q25 and on Chr 17q12 or...

Acetyl-CoA Carboxylase ; Adipose Tissue ; ANALYSIS ; Animals ; Chick Embryo ; CHROMOSOME ; Chromosome Mapping ; Chromosomes,Human,Pair 17 ; ENZYME ; ENZYMES ; Fatty Acid Synthetase Complex ; GENES ; GENETIQUE ; Humans ; Research Support,Non-U.S.Gov't ; Synteny
401150 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Expression of c-fos and jun protooncogenes in ovine trophoblasts in relation to interferon-tau expression and early implantation process   Xavier F ; Lagarrigue, Sandrine ; Guillomot M ; Gaillard-Sanchez I
Mol Reprod Dev, 1997 , Volume 2 , n° 46 , 127-137 p.   [ ISSN : 1040-452X ]
Résumé :
Expression of c-fos and jun protooncogenes was analyzed in the ovine extraembryonic trophoblast from days 14-18 of gestation, using Northern and Western blotting and immunohistochemistry. This study was carried out in relation to the early implantation process and the expression of...

Animals ; Antibodies ; Binding Sites ; Embryo Implantation ; Female ; FRANCE ; Gene Expression Regulation,Developmental ; GENETIQUE ; Humans ; Immunohistochemistry ; Interferon Type I ; Interferon Type II ; MALE ; METABOLISM ; Nuclear Proteins ; PHYSIOLOGIE ; Pregnancy Proteins ; Promoter Regions (Genetics) ; Proteins ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-fos ; Proto-Oncogene Proteins c-jun ; RATS ; RECHERCHE ; Sheep ; TRANSCRIPTION ; Transcription Factor AP-1 ; Trophoblasts
401152 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Mycobacterium tuberculosis Des protein: an immunodominant target for the humoral response of tuberculous patients   Jackson, Mary ; Portnoï, Denis ; Catheline, Daniel ; Dumail, Laure ; Rauzier, Jean ; Legrand, Philippe ; Gicquel, Brigitte
Infect Immun, 1997 , Volume 7 , n° 65 , 2883-2889 p.   [ ISSN : 0019-9567 ]
Résumé :
The phoA gene fusion methodology permitted the identification of a new Mycobacterium tuberculosis exported protein, Des. This protein has significant sequence similarities to plant acyl-acyl carrier protein desaturases, which are enzymes involved in general fatty acid biosynthesis as well as in...

Amino Acid Sequence ; Animals ; Antibody Formation ; Antigens,Bacterial ; B-Lymphocytes ; Bacterial Proteins ; Biosynthesis ; CATTLE ; DESATURASE ; ENZYME ; ENZYMES ; Humans ; immunology ; Molecular Sequence Data ; MYCOBACTERIUM TUBERCULOSIS ; PARIS ; Proteins ; Research Support,Non-U.S.Gov't ; Research Support,U.S.Gov't,P.H.S. ; Tuberculosis ; Tuberculosis,Pulmonary
401127 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Cloning and characterization of the 5' end and promoter region of the chicken acetyl-CoA carboxylase gene   El Khadir-Mounier, Catherine ; Le Fur, Nathalie ; Powell, Rohan S. ; Diot, Christian ; Langlois P ; Mallard, Jacques ; Douaire, Madeleine
Biochem J, 1996 , n° 314 ( Pt 2) , 613-619 p.   [ ISSN : 0264-6021 ]
Résumé :
Acetyl-CoA carboxylase is a rate-limiting enzyme in the biogenesis of long-chain fatty acids. In the present study, the 5' end and flanking region of the acetyl-CoA carboxylase (ACC) gene was analysed in the chicken. A genomic clone was isolated containing the first three exons, the third one...

Acetyl-CoA Carboxylase ; ANALYSE ; ANALYSIS ; Animals ; Base Sequence ; Cell Line ; Chickens ; Cloning,Molecular ; DNA ; DNA,Complementary ; ENZYME ; EXONS ; Fatty Acids ; Gene Expression ; GENETIQUE ; Humans ; Liver ; Molecular Sequence Data ; PCR ; Polymerase Chain Reaction ; Promoter Regions (Genetics) ; RAT ; Research Support,Non-U.S.Gov't ; Restriction Mapping ; RNA ; RNA Splicing ; RNA,Messenger ; TRANSCRIPTION ; Transcription,Genetic ; TRANSFECTION
401088 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Liposomal amphotericin B bases of therapeutic index increase   Legrand P ; Vertut-Doi A ; Bolard J
Biomater Artif Cells Immobilization Biotechnol, 1993 , Volume 3 , n° 21 , 407-413 p.   [ ISSN : 1055-7172 ]
Résumé :
Liposomes represent for amphotericin B (AmB) a promising delivery system that may reduce the important toxicity of the drug. Liposomal AmB has a higher therapeutic index than AmB alone and allows to use larger doses. The mechanism of reduced toxicity may be related to a better targeting ability,...

Administration & dosage ; Amphotericin B ; Animals ; Drug Carriers ; Humans ; Liposomes ; PARIS ; TOXICITY
401094 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Effects of aggregation and solvent on the toxicity of amphotericin B to human erythrocytes   Legrand, Philippe ; Romero, Eneida A. ; Cohen, B. Eleazar ; Bolard, Jacques
Antimicrobial Agents and Chemotherapy, 1992 , Volume 11 , n° 36 , 2518-2522 p.   [ ISSN : 0066-4804 ]
Résumé :
In aqueous suspensions of amphotericin B (AmB), a polyene antibiotic and antifungal agent, three forms of AmB coexist: monomers, water-soluble oligomers, and non-water-soluble aggregates. The toxicity of the water-soluble self-associated form of AmB compared with that of the non-water-soluble...

Amphotericin B ; Cell Membrane Permeability ; CHEMISTRY ; Chemistry,Pharmaceutical ; CHOLESTEROL ; Circular Dichroism ; Comparative Study ; Dimethyl Sulfoxide ; Dimethylformamide ; Drug effects ; Erythrocyte Membrane ; Erythrocytes ; FRANCE ; Humans ; Kinetics ; METABOLISM ; PARIS ; pharmacokinetics ; pharmacology ; POTASSIUM ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Solubility ; TOXICITY
401082 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Diagnosis of nosocomial pneumonia in mechanically ventilated patients. Comparison of a plugged telescoping catheter with the protected specimen brush   Pham, Lang Ha ; Brun-Buisson, Christian ; Legrand, Patrick ; Rauss, Alain ; Verra, Fernando ; Brochard, Laurent ; Lemaire, François
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991 , Volume 5 Pt 1 , n° 143 , 1055-1061 p.   [ ISSN : 0003-0805 ]
Résumé :
Protected samples of lower respiratory tract secretions processed by quantitative culture techniques are recommended to diagnose nosocomial bacterial pneumonia in intubated, mechanically ventilated patients. To evaluate the accuracy of a simple and inexpensive sampling device in this setting, we...

Bacterial Infections ; Bacteriological Techniques ; Bronchoscopy ; Catheterization ; Comparative Study ; Cross Infection ; DIAGNOSIS ; Female ; FRANCE ; Humans ; INSTRUMENTATION ; MALE ; Middle Aged ; Pneumonia ; Respiration,Artificial ; SECRETION ; Sensitivity and Specificity ; Specimen Handling
401074 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium   Bolard J ; Legrand P ; Heitz F ; Cybulska B
Biochemistry, 1991 , Volume 23 , n° 30 , 5707-5715 p.   [ ISSN : 0006-2960 ]
Résumé :
The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtained with cholesterol- and ergosterol-containing egg yolk phosphatidylcholine large unilamellar vesicles...

ABSORPTION ; Amphotericin B ; Buffers ; Cell Membrane Permeability ; CHEMISTRY ; CHOLESTEROL ; Circular Dichroism ; Drug effects ; Electrochemistry ; Ergosterol ; Erythrocyte Membrane ; Erythrocytes ; Humans ; Liposomes ; METABOLISM ; Nystatin ; pharmacology ; Phosphatidylcholines ; POTASSIUM ; Research Support,Non-U.S.Gov't ; Saccharomyces cerevisiae ; WATER
401091 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Antibacterial effect of cefixime in the presence of the type of beta-lactamases produced by Enterobacteriaceae   Philippon, Alain ; Jarlier, Vincent ; Legrand, Philippe ; Fournier, Geneviève ; Nicolas, Marie-Hélène ; Duval, J.
PRESSE MEDICALE, 1989 , Volume 18 , n° 18 , 1560-1566 p.   [ ISSN : 0755-4982 ]
Résumé :
The susceptibility of isolates or Enterobacteriaceae to orally absorbed beta-lactams (amoxicillin, cephalexin, cefaclor, cefuroxime, and cefixime), was maximum for the iminomethoxy-aminothiazolyl-cephalosporin but variable according to bacterial species. For E. coli, P. mirabilis, Salmonella,...

Amoxicillin ; analogs & derivatives ; Anti-Bacterial Agents ; Aztreonam ; beta-Lactamases ; Biosynthesis ; Cefixime ; Cefotaxime ; Comparative Study ; Dose-Response Relationship,Drug ; Drug effects ; English Abstract ; Enterobacteriaceae ; ENZYME ; Enzymology ; ESCHERICHIA COLI ; Humans ; Klebsiella ; Klebsiella pneumoniae ; PARIS ; Penicillin Resistance ; pharmacology ; PHENOTYPE
401165 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Detection of extended broad-spectrum beta-lactamases in Enterobacteriaceae in four French hospitals   Legrand, Philippe ; Fournier, Geneviève ; Bure A ; Jarlier, Vincent ; Nicolas, Marie-Hélène ; Decre D ; Duval, J. ; Philippon, Alain
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES, 1989 , Volume 8 , n° 8 , 527-529 p.   [ ISSN : 0934-9723 ]
Résumé :
In 210 strains of Enterobacteriaceae which were isolated in four hospitals and which showed reduced susceptibility to cefotaxime, high synergy was demonstrated between amoxicillin (20 micrograms) + clavulanate (10 micrograms) and cefotaxime (30 micrograms) using a simple double-disk test....

Amoxicillin ; Amoxicillin-Potassium Clavulanate Combination ; Antibiotics,Combined ; beta-Lactamases ; Cefotaxime ; Citrobacter ; Clavulanic Acid ; Clavulanic Acids ; Drug effects ; Drug Resistance,Microbial ; Drug Synergism ; Enterobacter ; Enterobacteriaceae ; Enzymology ; ESCHERICHIA COLI ; FRANCE ; Humans ; Isoelectric Point ; Isolation & purification ; METABOLISM ; Microbial Sensitivity Tests ; Penicillin Resistance ; pharmacology ; Serratia marcescens
401116 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Intestinal decontamination for control of nosocomial multiresistant gram-negative bacilli. Study of an outbreak in an intensive care unit   Brun-Buisson, Christian ; Legrand, Patrick ; Rauss, Alain ; Richard, Claude ; Montravers, Françoise ; Besbes, Mohamed ; Meakins, Jonathan L. ; Soussy, Claude J. ; Lemaire, François
Annals of Internal Medicine, 1989 , Volume 110 , n° 110 , 873-881 p.   [ ISSN : 0003-4819 ]
Résumé :
STUDY OBJECTIVE: To study the efficacy of intestinal decontamination by oral nonabsorbable antibiotic agents to control a nosocomial outbreak of intestinal colonization and infection with multiresistant Enterobacteriaceae, and to examine its effects on endemic nosocomial infection rates. DESIGN:...

Adult ; Aged ; Anti-Bacterial Agents ; Cephalosporins ; Colistin ; Cross Infection ; Disease Outbreaks ; Drug effects ; Drug Resistance,Microbial ; Drug Therapy,Combination ; Enterobacteriaceae ; Enterobacteriaceae Infections ; Humans ; INFECTION ; Intensive Care Units ; Intestines ; Klebsiella pneumoniae ; MICROBIOLOGY ; Middle Aged ; Nalidixic Acid ; Neomycin ; PARIS ; pharmacology ; prevention & control ; Random Allocation ; RISK FACTORS ; therapeutic use
401080 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Activity of 9 beta-lactam antibiotics combined with clavulanic acid or sulbactam against the strains of broad-spectrum beta-lactamase (CTX-1) producing Enterobacteriaceae isolated at the Henri Mondor Hospital   Legrand P ; Soussy CJ ; Orsoni A ; Brickley X ; Duval, J.
Pathol Biol (Paris), 1988 , Volume 5 , n° 36 , 425-429 p.   [ ISSN : 0369-8114 ]
Résumé :
Minimal inhibitory concentrations (MICs) of seven cephalosporins: cefotaxime (CTX), ceftriaxone (CRO), ceftazidime (CAZ), latamoxef (MOX), cefoxitin (FOX), cefotetan (CTT) and CM 40876 (CM), of aztreonam (ATM) and imipenem (IPM) were evaluated by agar dilution with and without 5 mg/l of...

Anti-Bacterial Agents ; Aztreonam ; beta-Lactamases ; Biosynthesis ; Cefotaxime ; Cephalosporins ; Citrobacter ; Clavulanic Acid ; Clavulanic Acids ; Comparative Study ; Drug effects ; Drug Resistance,Microbial ; Drug Synergism ; English Abstract ; Enterobacter ; Enterobacteriaceae ; Enzymology ; ESCHERICHIA COLI ; Humans ; Imipenem ; Klebsiella ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; pharmacology ; Sulbactam ; Thienamycins
401157 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie
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