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Gene Expression
0 sélectionnée(s) / 19 réponse(s)  

Article A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension   Bellenger J ; Bellenger S ; Clement L ; Mandard S ; Diot, Christian ; Poisson, Jean-Pierre ; Narce, Michel
FASEB J, 2004 , Volume 6 , n° 18 , 773-775 p.   [ ISSN : 1530-6860 ]
Résumé :
Polyunsaturated fatty acids (PUFA) are known to repress SCD-1 gene expression, key enzyme of monounsaturated fatty acid biosynthesis. Alterations of the monounsaturated/saturated fatty acids ratio have been implicated in various diseases related to the metabolic syndrome, including hypertension....

Administration & dosage ; Administration,Oral ; Aliments ; ANALYSIS ; Animals ; Biosynthesis ; Blood ; Blood Pressure ; CHEMISTRY ; ENZYME ; Enzymology ; Fatty Acids ; Fatty Acids,Unsaturated ; Gene Expression ; Gene Expression Regulation,Enzymologic ; GENETIQUE ; HEPATOCYTE ; Hypertension ; LIPIDES ; Lipids ; Liver ; Metaboslim ; Models,Biological ; NUTRITION ; Oleic Acid ; pharmacology ; PLASMA ; RAT ; RATS ; Rats,Inbred SHR ; Rats,Inbred WKY ; Stearoyl-CoA Desaturase ; TRANSCRIPTION ; TRIGLYCERIDES
401117 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Cloning and characterization of HEP21, a new member of the uPAR/Ly6 protein superfamily predominantly expressed in hen egg white   Nau, Françoise ; Guérin-Dubiard, Catherine ; Désert, Colette ; Gautron, Joël ; Bouton S ; Gribonval J ; Lagarrigue, Sandrine
Poult Sci, 2003 , Volume 2 , n° 82 , 242-250 p.   [ ISSN : 0032-5791 ]
Résumé :
Using two-dimensional (2D)-PAGE, partial protein internal sequencing, and PCR with degenerate primers, we cloned a novel cDNA named HEP21 from hen egg white. The 0.5-kb cDNA encodes a 106 amino acid protein with a cysteine spacing pattern suggesting that HEP21 is a new member of the...

Amino Acid Sequence ; ANALYSIS ; Animals ; Base Sequence ; cDNA ; CHEMISTRY ; Chickens ; Cloning,Molecular ; Comparative Study ; DNA ; DNA,Complementary ; Egg Proteins ; Egg White ; Electrophoresis,Gel,Two-Dimensional ; Female ; Gene Expression ; GENETIQUE ; Metaboslim ; Molecular Sequence Data ; Oviducts ; PCR ; Random Amplified Polymorphic DNA Technique ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Analysis,Protein ; Sequence Homology
401162 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Cloning of cDNA encoding the nuclear form of chicken sterol response element binding protein-2 (SREBP-2), chromosomal localization, and tissue expression of chicken SREBP-1 and -2 genes   Assaf, Sirine ; Hazard, Dominique ; Pitel, Frédérique ; Morisson, Mireille ; Alizadeh, Mehdi ; Gondret, Florence ; Diot, Christian ; Vignal, Alain ; Douaire, Madeleine ; Lagarrigue, Sandrine
Poult Sci, 2003 , Volume 1 , n° 82 , 54-61 p.   [ ISSN : 0032-5791 ]
Résumé :
Sterol regulatory element binding protein-1 and -2 (SREBP-1 and -2) are key transcription factors involved in the biosynthesis of cholesterol and fatty adds. The SREBP have mainly been studied in rodents in which lipogenesis is regulated in both liver and adipose tissue. There is, however, a...

Adipose Tissue ; Amino Acid Sequence ; ANALYSIS ; Animals ; Biosynthesis ; Blotting,Northern ; CCAAT-Enhancer-Binding Proteins ; cDNA ; CHEMISTRY ; Chickens ; CHROMOSOME ; Chromosome Mapping ; Chromosomes ; Cloning,Molecular ; Comparative Study ; CONSERVATION ; DNA ; DNA,Complementary ; DNA-Binding Proteins ; Gene Expression ; GENES ; GENETIQUE ; Hamsters ; Humans ; Liver ; METABOLISM ; Metaboslim ; Mice ; Molecular Sequence Data ; Organ Specificity ; Polymorphism,Genetic ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; RNA ; RNA,Messenger ; Sequence Homology ; TRANSCRIPTION ; Transcription Factors
401159 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Colloque Lipogenic gene expression and genetic association with fatness in broiler chicken lines ( 2002 ) Assaf, Sirine ; Lagarrigue, Sandrine ; Daval, Stéphanie ; Le Nigen C ; Sansom, Manuella ; Leclercq, Bernard ; Michel, Joël ; Vignal, Alain ; Pitel, Frédérique ; Douaire, Madeleine  
401185 : Bibliothèque générale de Rennes (Sciences animales)
Gene Expression

Article Effects of polyunsaturated fatty acids and clofibrate on chicken stearoyl-coA desaturase 1 gene expression   Lefèvre, Pascal ; Tripon, Eddy ; Plumelet, Céline ; Douaire, Madeleine ; Diot, Christian
Biochem Biophys Res Commun, 2001 , Volume 1 , n° 280 , 25-31 p.   [ ISSN : 0006-291X ]
Résumé :
In chicken, adiposity is influenced by hepatic stearoyl-CoA desaturase (SCD) 1. This gene is up-regulated by low-fat high-carbohydrate diet and down-regulated by addition of polyunsaturated fatty acids (PUFA). In this study, we present evidence for an inhibition of chicken SCD1 expression by PUFA...

5,8,11,14-Eicosatetraynoic Acid ; ANALYSE ; Animals ; Arachidonic Acid ; Base Sequence ; Chickens ; Clofibrate ; Drug effects ; Fatty Acids ; Fatty Acids,Unsaturated ; Gene Expression ; Gene Expression Regulation,Enzymologic ; GENES ; Genes,Reporter ; GENETIQUE ; Insulin ; Luciferases ; Molecular Sequence Data ; pharmacology ; Promoter Regions (Genetics) ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Stearoyl-CoA Desaturase ; Tata Box ; TRANSFECTION ; Tumor Cells,Cultured
401086 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption   Lagarrigue, Sandrine ; Daval, Stéphanie ; Bordas A ; Douaire, Madeleine
Genet Sel Evol, 2000 , Volume 2 , n° 32 , 205-216 p.   [ ISSN : 0999-193X ]
Résumé :
Two Rhode Island Red egg-laying lines have been divergently selected on residual food intake (low intake R- line, high intake R+ line) for 19 generations. In addition to direct response, correlated responses have altered several other traits such as carcass adiposity and lipid contents of several...

Acetyl-CoA Carboxylase ; Adipose Tissue ; ANIMAL ; Animals ; ENZYME ; Gene Expression ; GENES ; METABOLISM ; Metaboslim ; RECHERCHE ; Stearoyl-CoA Desaturase ; TRANSCRIPTION
401122 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Stearoyl-CoA desaturase 1 coding sequences and antisense RNA affect lipid secretion in transfected chicken LMH hepatoma cells   Diot, Christian ; Lefèvre, Pascal ; Hervé, Christophe ; Belloir, Bénédicte ; Narce, Michel ; Damon, Marie ; Poisson, Jean-Pierre ; Mallard, Jacques ; Douaire, Madeleine
Arch Biochem Biophys, 2000 , Volume 2 , n° 380 , 243-250 p.   [ ISSN : 0003-9861 ]
Résumé :
Hepatic stearoyl CoA desaturase (SCD) activity in chickens from a fat line is higher than that of chickens from a lean line and correlates with plasma triacylglycerol concentrations. Furthermore, in these lines, the hepatic SCD1 mRNA level is positively correlated with the adipose tissue weight....

Adipose Tissue ; Animals ; Base Sequence ; Chickens ; DNA ; DNA Primers ; Drug effects ; Enzymology ; Gene Expression ; GENETIQUE ; ISOENZYMES ; Lipids ; Liver ; Liver Neoplasms,Experimental ; LMH ; Metaboslim ; pharmacology ; PLASMA ; Recombinant Proteins ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Antisense ; RNA,Messenger ; RNA,Neoplasm ; SECRETION ; Secrétion ; Stearoyl-CoA Desaturase ; TRANSFECTION ; Tumor Cells,Cultured
401083 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Hormonal regulation of stearoyl coenzyme-A desaturase 1 activity and gene expression in primary cultures of chicken hepatocytes   Lefèvre, Pascal ; Diot, Christian ; Legrand, Philippe ; Douaire, Madeleine
Arch Biochem Biophys, 1999 , Volume 2 , n° 368 , 329-337 p.   [ ISSN : 0003-9861 ]
Résumé :
Previous studies have provided evidence for the important role of liver stearoyl-CoA desaturase (SCD) in excessive adiposity in the chicken and suggest that the difference in SCD activity between fat and lean chickens could be explained by a difference in SCD1 gene expression. In the present...

ANALYSIS ; Animals ; BIOCHIMIE ; Cells,Cultured ; Chickens ; DESATURASE ; Drug effects ; ENZYME ; Enzymology ; FRANCE ; Gene Expression ; Gene Expression Regulation,Enzymologic ; GENES ; GENETIQUE ; GLUCAGON ; HEPATOCYTE ; Hypoglycemic Agents ; Insulin ; Liver ; METABOLISM ; pharmacology ; Protein Synthesis Inhibitors ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Stearoyl-CoA Desaturase ; TRANSCRIPTION
401084 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Colloque Stearoyl-CoA desaturase 1 gene expression, a model for the study of the regulation of lipid metabolism in the chicken ( 1999 ) Lefèvre, Pascal ; Plumelet, Céline ; Tripon, Eddy ; Douaire, Madeleine ; Diot, Christian  
401269 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
Gene Expression ; Lipids ; METABOLISM ; Stearoyl-CoA Desaturase

Colloque Effects of polyunsaturated fatty acids and peroroxisome-proliferators on stearoyl-CoA desaturase 1 gene expression in chicken hepatoma cells ( 1998 ) Diot, Christian ; Lefèvre, Pascal ; Tripon, Eddy ; Quelen, François de ; Douaire, Madeleine  
401214 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
Fatty Acids ; Gene Expression ; NUTRITION ; Stearoyl-CoA Desaturase

Colloque Lipogenesis gene expression in divergently selected lean and fat chickens ( 1998 ) Daval, Stéphanie ; Lagarrigue, Sandrine ; Caffin JP ; Leclercq, Bernard ; Douaire, Madeleine  
401205 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
Chickens ; Gene Expression

Colloque Lipogenic gene expression in divergently selected egg-laying lines on residual food consumption ( 1998 ) Lagarrigue, Sandrine ; Bordas A ; Daval, Stéphanie ; Douaire, Madeleine  
401258 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
Gene Expression

Colloque Régulation of stearoyl-CoA desaturase 1 gene expression by polyunsaturated-fatty acids and peroxisome-proliferators in the chicken ( 1998 ) Diot, Christian ; Lefèvre, Pascal ; Tripon, Eddy ; Quelen, François de ; Douaire, Madeleine  
401215 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
ANIMAL ; Gene Expression ; GENETIQUE ; Peroxisome Proliferators ; Stearoyl-CoA Desaturase

Colloque Regulation of the chicken stearoyl CoA desaturase gene expression in the chicken LMH cell line ( 1998 ) Lefèvre, Pascal ; Diot, Christian ; Tripon, Eddy ; Douaire, Madeleine  
401268 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
Cell Line ; Gene Expression ; LMH

Article Triglyceride synthesis and secretion and lipogenesis implicated gene expression in the chicken hepatocarcinoma cell line LMH   Belloir, Bénédicte ; Diot, Christian ; Douaire, Madeleine
Eur J Cell Biol, 1997 , Volume 3 , n° 74 , 246-250 p.   [ ISSN : 0171-9335 ]
Résumé :
Avian lipogenesis was studied in the chicken hepatocarcinoma LMH cell line. The differentiated and lipogenic status of these cells was evidenced by the presence of the albumin mRNA as well as of some mRNA coding for enzymes involved in lipogenesis (acetyl-CoA carboxylase, fatty acid synthase,...

Acetyl-CoA Carboxylase ; ANALYSIS ; Animals ; Apoproteins ; Biosynthesis ; Cell Line ; Chickens ; ENZYME ; ENZYMES ; Gene Expression ; GLUCAGON ; HEPATOCYTE ; HORMONES ; Insulin ; Lipids ; Liver ; Liver Neoplasms ; LMH ; METABOLISM ; pharmacology ; Research Support,Non-U.S.Gov't ; SECRETION ; TRIGLYCERIDES ; Tumor Cells,Cultured
401114 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Cloning and characterization of the 5' end and promoter region of the chicken acetyl-CoA carboxylase gene   El Khadir-Mounier, Catherine ; Le Fur, Nathalie ; Powell, Rohan S. ; Diot, Christian ; Langlois P ; Mallard, Jacques ; Douaire, Madeleine
Biochem J, 1996 , n° 314 ( Pt 2) , 613-619 p.   [ ISSN : 0264-6021 ]
Résumé :
Acetyl-CoA carboxylase is a rate-limiting enzyme in the biogenesis of long-chain fatty acids. In the present study, the 5' end and flanking region of the acetyl-CoA carboxylase (ACC) gene was analysed in the chicken. A genomic clone was isolated containing the first three exons, the third one...

Acetyl-CoA Carboxylase ; ANALYSE ; ANALYSIS ; Animals ; Base Sequence ; Cell Line ; Chickens ; Cloning,Molecular ; DNA ; DNA,Complementary ; ENZYME ; EXONS ; Fatty Acids ; Gene Expression ; GENETIQUE ; Humans ; Liver ; Molecular Sequence Data ; PCR ; Polymerase Chain Reaction ; Promoter Regions (Genetics) ; RAT ; Research Support,Non-U.S.Gov't ; Restriction Mapping ; RNA ; RNA Splicing ; RNA,Messenger ; TRANSCRIPTION ; Transcription,Genetic ; TRANSFECTION
401088 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Colloque Hormonal regulation of stearoyl-CoA desaturase 1 gene expression and activity in primary cultured chicken hepatocytes ( 1996 ) Lefèvre, Pascal ; Legrand, Philippe ; Douaire, Madeleine  
401267 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
ANIMAL ; CONGRES ; Gene Expression ; GENETIQUE ; GENETIQUE ANIMALE ; HEPATOCYTE ; Stearoyl-CoA Desaturase

Colloque Stearoyl coenzyme A desaturase gene expression and triglycerides secretion in LMH cells ( 1996 ) Diot, Christian ; Hervé, Christophe ; You V ; Sourdioux, Michel ; Douaire, Madeleine  
401212 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
Gene Expression ; LMH ; SECRETION ; TRIGLYCERIDES

Colloque Variation of reporter gene expression due to differences between plasmid preparations ( 1993 ) Powell, Rohan S. ; Le Fur, Nathalie ; Diot, Christian ; Douaire, Madeleine  
401287 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA
Gene Expression ; VARIATION