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Drug effects
0 sélectionnée(s) / 17 réponse(s)  

Article Myristic acid increases delta6-desaturase activity in cultured rat hepatocytes   Jan, Sophie ; Guillou, Hervé ; D'Andrea, Sabine ; Daval, Stéphanie ; Bouriel, Monique ; Rioux, Vincent ; Legrand, Philippe
Reproduction Nutrition Development, 2004 , Volume 44 , n° 44 , 131-140 p.   [ ISSN : 0926-5287 ]
Résumé :
In order to study the effects of saturated fatty acids on delta6-desaturase activity, rat hepatocytes in primary culture were incubated with lauric (C12:0), myristic (C14:0) or palmitic (C16:0) acids. After optimization, the standard in vitro conditions for the measurement of delta6-desaturase...

Animals ; BIOCHIMIE ; Cells,Cultured ; DESATURASE ; Dose-Response Relationship,Drug ; Drug effects ; Enzymology ; Fatty Acid Desaturases ; Fatty Acids ; FRANCE ; HEPATOCYTE ; Lauric Acids ; MALE ; METABOLISM ; Myristic Acid ; Oleic Acid ; Palmitic Acid ; pharmacology ; RAT ; RATS ; Rats,Sprague-Dawley ; Research Support,Non-U.S.Gov't
401166 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Comparative effect of fenofibrate on hepatic desaturases in wild-type and peroxisome proliferator-activated receptor alpha-deficient mice   Guillou, Hervé ; Martin, Pascal ; Jan, Sophie ; D'Andrea, Sabine ; Roulet, Alain ; Catheline, Daniel ; Rioux, Vincent ; Pineau, Thierry ; Legrand, Philippe
Lipids, 2002 , Volume 37 , n° 37 , 981-989 p.   [ ISSN : 0024-4201 ]
Résumé :
In this study is presented the effect of fenofibrate, a prototypical peroxisome proliferator of the fibrate class, on wild-type and peroxisome proliferator-activated receptor alpha (PPARalpha)-/- mouse liver FA profile, desaturase mRNA levels, and activities. We established that, following...

ANALYSIS ; Animals ; BIOCHIMIE ; Body Weight ; deficiency ; DESATURASE ; Drug effects ; Enzymology ; Fatty Acid Desaturases ; Fatty Acids ; FRANCE ; GENETIQUE ; Liver ; MALE ; METABOLISM ; Mice ; Mice,Knockout ; Organ Size ; pharmacology ; Procetofen ; Receptors,Cytoplasmic and Nuclear ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Time Factors ; TRANSCRIPTION ; Transcription Factors
401147 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Effects of polyunsaturated fatty acids and clofibrate on chicken stearoyl-coA desaturase 1 gene expression   Lefèvre, Pascal ; Tripon, Eddy ; Plumelet, Céline ; Douaire, Madeleine ; Diot, Christian
Biochem Biophys Res Commun, 2001 , Volume 1 , n° 280 , 25-31 p.   [ ISSN : 0006-291X ]
Résumé :
In chicken, adiposity is influenced by hepatic stearoyl-CoA desaturase (SCD) 1. This gene is up-regulated by low-fat high-carbohydrate diet and down-regulated by addition of polyunsaturated fatty acids (PUFA). In this study, we present evidence for an inhibition of chicken SCD1 expression by PUFA...

5,8,11,14-Eicosatetraynoic Acid ; ANALYSE ; Animals ; Arachidonic Acid ; Base Sequence ; Chickens ; Clofibrate ; Drug effects ; Fatty Acids ; Fatty Acids,Unsaturated ; Gene Expression ; Gene Expression Regulation,Enzymologic ; GENES ; Genes,Reporter ; GENETIQUE ; Insulin ; Luciferases ; Molecular Sequence Data ; pharmacology ; Promoter Regions (Genetics) ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Stearoyl-CoA Desaturase ; Tata Box ; TRANSFECTION ; Tumor Cells,Cultured
401086 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Stearoyl coenzyme A desaturase 1 expression and activity are increased in the liver during iron overload   Pigeon, Christelle ; Legrand, Philippe ; Leroyer, Patricia ; Bouriel, Monique ; Turlin, Bruno ; Brissot, Pierre ; Loreal, Olivier
Biochimica et Biophysica Acta, 2001 , Volume 3 , n° 1535 , 275-284 p.   [ ISSN : 0006-3002 ]
Résumé :
In humans, hepatic iron overload can lead to hepatocellular carcinoma development. Iron related dysregulation of hepatic genes could play a role in this phenomenon. We previously found that the carbonyl-iron overloaded mouse was a useful model to study the mechanisms involved in the development...

ANALYSIS ; Animals ; Biosynthesis ; DESATURASE ; Disease Models,Animal ; Drug effects ; ENZYME ; Enzyme Activation ; Enzymology ; Fatty Acids ; FOIE ; FRANCE ; Gene Expression Regulation ; GENES ; GENETIQUE ; Humans ; Iron Overload ; Iron-Dextran Complex ; Liver ; MALE ; METABOLISM ; Mice ; Mice,Inbred BALB C ; Organometallic Compounds ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Stearoyl-CoA Desaturase ; Up-Regulation
401093 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Stearoyl-CoA desaturase 1 coding sequences and antisense RNA affect lipid secretion in transfected chicken LMH hepatoma cells   Diot, Christian ; Lefèvre, Pascal ; Hervé, Christophe ; Belloir, Bénédicte ; Narce, Michel ; Damon, Marie ; Poisson, Jean-Pierre ; Mallard, Jacques ; Douaire, Madeleine
Arch Biochem Biophys, 2000 , Volume 2 , n° 380 , 243-250 p.   [ ISSN : 0003-9861 ]
Résumé :
Hepatic stearoyl CoA desaturase (SCD) activity in chickens from a fat line is higher than that of chickens from a lean line and correlates with plasma triacylglycerol concentrations. Furthermore, in these lines, the hepatic SCD1 mRNA level is positively correlated with the adipose tissue weight....

Adipose Tissue ; Animals ; Base Sequence ; Chickens ; DNA ; DNA Primers ; Drug effects ; Enzymology ; Gene Expression ; GENETIQUE ; ISOENZYMES ; Lipids ; Liver ; Liver Neoplasms,Experimental ; LMH ; Metaboslim ; pharmacology ; PLASMA ; Recombinant Proteins ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Antisense ; RNA,Messenger ; RNA,Neoplasm ; SECRETION ; Secrétion ; Stearoyl-CoA Desaturase ; TRANSFECTION ; Tumor Cells,Cultured
401083 : Bibliothèque générale de Rennes (Sciences animales) - Cote = UMR GA

Article Hormonal regulation of stearoyl coenzyme-A desaturase 1 activity and gene expression in primary cultures of chicken hepatocytes   Lefèvre, Pascal ; Diot, Christian ; Legrand, Philippe ; Douaire, Madeleine
Arch Biochem Biophys, 1999 , Volume 2 , n° 368 , 329-337 p.   [ ISSN : 0003-9861 ]
Résumé :
Previous studies have provided evidence for the important role of liver stearoyl-CoA desaturase (SCD) in excessive adiposity in the chicken and suggest that the difference in SCD activity between fat and lean chickens could be explained by a difference in SCD1 gene expression. In the present...

ANALYSIS ; Animals ; BIOCHIMIE ; Cells,Cultured ; Chickens ; DESATURASE ; Drug effects ; ENZYME ; Enzymology ; FRANCE ; Gene Expression ; Gene Expression Regulation,Enzymologic ; GENES ; GENETIQUE ; GLUCAGON ; HEPATOCYTE ; Hypoglycemic Agents ; Insulin ; Liver ; METABOLISM ; pharmacology ; Protein Synthesis Inhibitors ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Stearoyl-CoA Desaturase ; TRANSCRIPTION
401084 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Effect of insulin on triacylglycerol synthesis and secretion by chicken hepatocytes in primary culture   Legrand, Philippe ; Catheline, Daniel ; Le Bihan, Elisabeth ; Lemarchal, Philippe
Int J Biochem Cell Biol, 1996 , Volume 4 , n° 28 , 431-440 p.   [ ISSN : 0020-711X ]
Résumé :
A primary culture system of chicken hepatocytes was developed to study the effects of genetic, hormonal and nutritional factors on hepatic triglyceride (TG) secretion in the chicken, and the effect of insulin on TG synthesis and secretion examined. TG synthesis and secretion was measured using...

ANALYSIS ; Animals ; BIOCHIMIE ; Biosynthesis ; Cells,Cultured ; Chickens ; Culture Media ; cytology ; Drug effects ; Fatty Acids ; FRANCE ; HEPATOCYTE ; Insulin ; Liver ; MALE ; METABOLISM ; Oleic Acid ; pharmacology ; PHYSIOLOGY ; Research Support,Non-U.S.Gov't ; SECRETION ; TRIGLYCERIDES
401134 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Stearoyl-CoA desaturase activity in primary culture of chicken hepatocytes. Influence of insulin, glucocorticoid, fatty acids and cordycepin   Legrand, Philippe ; Catheline, Daniel ; Hannetel, Jean-Michel ; Lemarchal, Philippe
Int J Biochem, 1994 , Volume 6 , n° 26 , 777-785 p.   [ ISSN : 0020-711X ]
Résumé :
1. Stearoyl-CoA desaturase (delta 9-desaturase) activity was measured in chicken primary hepatocytes, as a function of time in culture. 2. When using fasted donor animals, the desaturase activity was low at the beginning of culture and then increased steadily to a maximum value between 30 and 70...

ANIMAL ; Animals ; BIOCHIMIE ; Cells,Cultured ; Chickens ; Culture Media ; cytology ; Deoxyadenosines ; DESATURASE ; Dexamethasone ; Drug effects ; ENZYME ; Enzymology ; Fasting ; Fatty Acids ; FRANCE ; GENETIQUE ; HEPATOCYTE ; Insulin ; Linoleic Acid ; Linoleic Acids ; Liver ; MALE ; METABOLISM ; pharmacology ; Protein Biosynthesis ; Research Support,Non-U.S.Gov't ; RNA ; RNA,Messenger ; Stearoyl-CoA Desaturase
401133 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Effects of aggregation and solvent on the toxicity of amphotericin B to human erythrocytes   Legrand, Philippe ; Romero, Eneida A. ; Cohen, B. Eleazar ; Bolard, Jacques
Antimicrobial Agents and Chemotherapy, 1992 , Volume 11 , n° 36 , 2518-2522 p.   [ ISSN : 0066-4804 ]
Résumé :
In aqueous suspensions of amphotericin B (AmB), a polyene antibiotic and antifungal agent, three forms of AmB coexist: monomers, water-soluble oligomers, and non-water-soluble aggregates. The toxicity of the water-soluble self-associated form of AmB compared with that of the non-water-soluble...

Amphotericin B ; Cell Membrane Permeability ; CHEMISTRY ; Chemistry,Pharmaceutical ; CHOLESTEROL ; Circular Dichroism ; Comparative Study ; Dimethyl Sulfoxide ; Dimethylformamide ; Drug effects ; Erythrocyte Membrane ; Erythrocytes ; FRANCE ; Humans ; Kinetics ; METABOLISM ; PARIS ; pharmacokinetics ; pharmacology ; POTASSIUM ; RECHERCHE ; Research Support,Non-U.S.Gov't ; Solubility ; TOXICITY
401082 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium   Bolard J ; Legrand P ; Heitz F ; Cybulska B
Biochemistry, 1991 , Volume 23 , n° 30 , 5707-5715 p.   [ ISSN : 0006-2960 ]
Résumé :
The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtained with cholesterol- and ergosterol-containing egg yolk phosphatidylcholine large unilamellar vesicles...

ABSORPTION ; Amphotericin B ; Buffers ; Cell Membrane Permeability ; CHEMISTRY ; CHOLESTEROL ; Circular Dichroism ; Drug effects ; Electrochemistry ; Ergosterol ; Erythrocyte Membrane ; Erythrocytes ; Humans ; Liposomes ; METABOLISM ; Nystatin ; pharmacology ; Phosphatidylcholines ; POTASSIUM ; Research Support,Non-U.S.Gov't ; Saccharomyces cerevisiae ; WATER
401091 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Stearyl-CoA desaturase activity in cultured rat hepatocytes   Legrand, Philippe ; Bensadoun, André
Biochim Biophys Acta, 1991 , Volume 1 , n° 1086 , 89-94 p.   [ ISSN : 0006-3002 ]
Résumé :
Stearyl-CoA desaturase activity was measured as a function of time in culture in rat primary hepatocytes up to 90 h of culture. A decrease to half of the original activity occurred within 40 h of culture. Activity remained constant thereafter. Stearyl-CoA desaturase activity increased with...

Animals ; BIOCHIMIE ; Cells,Cultured ; CHOLESTEROL ; cytology ; DESATURASE ; Dexamethasone ; DNA ; Drug effects ; ENZYME ; Enzymology ; FRANCE ; FRUCTOSE ; HEPATOCYTE ; Insulin ; Liver ; MALE ; METABOLISM ; pharmacology ; RAT ; RATS ; Rats,Inbred Strains ; Stearoyl-CoA Desaturase
401092 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Antibacterial effect of cefixime in the presence of the type of beta-lactamases produced by Enterobacteriaceae   Philippon, Alain ; Jarlier, Vincent ; Legrand, Philippe ; Fournier, Geneviève ; Nicolas, Marie-Hélène ; Duval, J.
PRESSE MEDICALE, 1989 , Volume 18 , n° 18 , 1560-1566 p.   [ ISSN : 0755-4982 ]
Résumé :
The susceptibility of isolates or Enterobacteriaceae to orally absorbed beta-lactams (amoxicillin, cephalexin, cefaclor, cefuroxime, and cefixime), was maximum for the iminomethoxy-aminothiazolyl-cephalosporin but variable according to bacterial species. For E. coli, P. mirabilis, Salmonella,...

Amoxicillin ; analogs & derivatives ; Anti-Bacterial Agents ; Aztreonam ; beta-Lactamases ; Biosynthesis ; Cefixime ; Cefotaxime ; Comparative Study ; Dose-Response Relationship,Drug ; Drug effects ; English Abstract ; Enterobacteriaceae ; ENZYME ; Enzymology ; ESCHERICHIA COLI ; Humans ; Klebsiella ; Klebsiella pneumoniae ; PARIS ; Penicillin Resistance ; pharmacology ; PHENOTYPE
401165 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Detection of extended broad-spectrum beta-lactamases in Enterobacteriaceae in four French hospitals   Legrand, Philippe ; Fournier, Geneviève ; Bure A ; Jarlier, Vincent ; Nicolas, Marie-Hélène ; Decre D ; Duval, J. ; Philippon, Alain
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES, 1989 , Volume 8 , n° 8 , 527-529 p.   [ ISSN : 0934-9723 ]
Résumé :
In 210 strains of Enterobacteriaceae which were isolated in four hospitals and which showed reduced susceptibility to cefotaxime, high synergy was demonstrated between amoxicillin (20 micrograms) + clavulanate (10 micrograms) and cefotaxime (30 micrograms) using a simple double-disk test....

Amoxicillin ; Amoxicillin-Potassium Clavulanate Combination ; Antibiotics,Combined ; beta-Lactamases ; Cefotaxime ; Citrobacter ; Clavulanic Acid ; Clavulanic Acids ; Drug effects ; Drug Resistance,Microbial ; Drug Synergism ; Enterobacter ; Enterobacteriaceae ; Enzymology ; ESCHERICHIA COLI ; FRANCE ; Humans ; Isoelectric Point ; Isolation & purification ; METABOLISM ; Microbial Sensitivity Tests ; Penicillin Resistance ; pharmacology ; Serratia marcescens
401116 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Intestinal decontamination for control of nosocomial multiresistant gram-negative bacilli. Study of an outbreak in an intensive care unit   Brun-Buisson, Christian ; Legrand, Patrick ; Rauss, Alain ; Richard, Claude ; Montravers, Françoise ; Besbes, Mohamed ; Meakins, Jonathan L. ; Soussy, Claude J. ; Lemaire, François
Annals of Internal Medicine, 1989 , Volume 110 , n° 110 , 873-881 p.   [ ISSN : 0003-4819 ]
Résumé :
STUDY OBJECTIVE: To study the efficacy of intestinal decontamination by oral nonabsorbable antibiotic agents to control a nosocomial outbreak of intestinal colonization and infection with multiresistant Enterobacteriaceae, and to examine its effects on endemic nosocomial infection rates. DESIGN:...

Adult ; Aged ; Anti-Bacterial Agents ; Cephalosporins ; Colistin ; Cross Infection ; Disease Outbreaks ; Drug effects ; Drug Resistance,Microbial ; Drug Therapy,Combination ; Enterobacteriaceae ; Enterobacteriaceae Infections ; Humans ; INFECTION ; Intensive Care Units ; Intestines ; Klebsiella pneumoniae ; MICROBIOLOGY ; Middle Aged ; Nalidixic Acid ; Neomycin ; PARIS ; pharmacology ; prevention & control ; Random Allocation ; RISK FACTORS ; therapeutic use
401080 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Activity of 9 beta-lactam antibiotics combined with clavulanic acid or sulbactam against the strains of broad-spectrum beta-lactamase (CTX-1) producing Enterobacteriaceae isolated at the Henri Mondor Hospital   Legrand P ; Soussy CJ ; Orsoni A ; Brickley X ; Duval, J.
Pathol Biol (Paris), 1988 , Volume 5 , n° 36 , 425-429 p.   [ ISSN : 0369-8114 ]
Résumé :
Minimal inhibitory concentrations (MICs) of seven cephalosporins: cefotaxime (CTX), ceftriaxone (CRO), ceftazidime (CAZ), latamoxef (MOX), cefoxitin (FOX), cefotetan (CTT) and CM 40876 (CM), of aztreonam (ATM) and imipenem (IPM) were evaluated by agar dilution with and without 5 mg/l of...

Anti-Bacterial Agents ; Aztreonam ; beta-Lactamases ; Biosynthesis ; Cefotaxime ; Cephalosporins ; Citrobacter ; Clavulanic Acid ; Clavulanic Acids ; Comparative Study ; Drug effects ; Drug Resistance,Microbial ; Drug Synergism ; English Abstract ; Enterobacter ; Enterobacteriaceae ; Enzymology ; ESCHERICHIA COLI ; Humans ; Imipenem ; Klebsiella ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; pharmacology ; Sulbactam ; Thienamycins
401157 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Dissemination in five French hospitals of Klebsiella pneumoniae serotype K25 harbouring a new transferable enzymatic resistance to third generation cephalosporins and aztreonam   Bure A ; Legrand, Philippe ; Arlet G ; Jarlier, Vincent ; Paul G ; Philippon, Alain
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES, 1988 , Volume 7 , n° 7 , 780-782 p.   [ ISSN : 0934-9723 ]
Résumé :
A strain of Klebsiella pneumoniae K25 resistant to newer beta-lactam drugs was isolated in clusters in five hospitals in the Paris area. The MICs of ceftazidime and aztreonam (greater than or equal to 128 mg/l) were higher than that of cefotaxime (16 mg/l) for the strain but, when measured in the...

Aztreonam ; beta-Lactamases ; Biosynthesis ; Cefotaxime ; Cephalosporins ; Clavulanic Acid ; Drug effects ; Drug Resistance,Microbial ; ENZYME ; FRANCE ; Isolation & purification ; Klebsiella ; Klebsiella pneumoniae ; PARIS ; pharmacology
401115 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie

Article Transferable enzymatic resistance to third-generation cephalosporins during nosocomial outbreak of multiresistant Klebsiella pneumoniae   Brun-Buisson, Christian ; Legrand, Patrick ; Philippon, Alain ; Montravers, Françoise ; Duval, Jean
Lancet, 1987 , Volume 330 , n° 2 , 302-306 p.   [ ISSN : 0140-6736 ]
Résumé :
Klebsiella pneumoniae strains that were resistant to third-generation cephalosporins and amikacin were recovered from 62 of 395 patients (15.7%) during 1986. 25 isolates (40%) caused urinary tract infections. The outbreak involved three intensive care units (54 isolates), and spread from one unit...

Amikacin ; ANALYSIS ; beta-Lactamases ; Cefotaxime ; Cephalosporins ; Clavulanic Acid ; Cross Infection ; Disease Outbreaks ; Drug effects ; Drug Resistance,Microbial ; drug therapy ; Enterobacteriaceae ; ENZYME ; epidemiology ; ESCHERICHIA COLI ; GENETIQUE ; Humans ; Intensive Care Units ; Isolation & purification ; Klebsiella ; Klebsiella Infections ; Klebsiella pneumoniae ; MICROBIOLOGY ; PARIS ; pharmacology ; Recurrence ; Sulbactam ; therapeutic use ; Urinary Tract Infections
401146 : Bibliothèque générale de Rennes (Sciences animales) - Cote = Publication Biochimie
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